This Month in JNM

September 3, 2016

ASNC/SNMMI PET Guideline highlights: Dilsizian provides an overview of an updated joint American Society of Nuclear Cardiology imaging guideline and SNMMI procedure standard for PET nuclear cardiology published in the September–October issue of the Journal of Nuclear Cardiology. Page 1327

Fluciclovine in breast cancer: McConathy offers perspective on the utility of this 18F-labeled amino acid agent in PET imaging in women with breast cancer naïve to therapy and discusses 2 related articles in this issue of JNM. Page 1329

In vivo cell tracking with PET: England and colleagues assess the potential and challenges for clinical PET biomarker imaging in progression and efficacy monitoring of transplanted stem cells in muscle-related diseases and review a related article in this month’s JNM. Page 1331

Molecular imaging in conditioning and response: Zhao and colleagues comment on the promise of advanced molecular imaging in exploring the neurofunctional mechanisms of classic conditioning and preview a related article in this issue of JNM. Page 1333

177Lu-PSMA therapy and advanced mCRPC: Rahbar and colleagues evaluate the response to and tolerability of a single dose of this prostate-specific membrane antigen ligand in a large cohort of patients with metastatic castration-resistant prostate cancer. Page 1334

124I PET/CT vs. 131I imaging: Ruhlmann and colleagues assess levels of agreement between PET and scintigraphy using diagnostic amounts of 124I and therapeutic amounts of 131I, respectively, in detecting iodine-positive metastases in patients with differentiated thyroid carcinoma. Page 1339

18F-FDG PET/CT repeatability in NSCLC: Kramer and colleagues investigate the repeatability of various quantitative whole-body 18F-FDG metrics in patients with non–small cell lung cancer as a function of tracer uptake interval and lesion selection strategies. Page 1343

18F-fluciclovine PET/CT in breast cancer: Ulaner and colleagues report on the imaging results of a prospective clinical trial of this leucine analog radiotracer in patients with newly diagnosed advanced local invasive ductal carcinoma and invasive lobular carcinoma. Page 1350

18F-fluciclovine uptake in breast cancer: Tade and colleagues explore the uptake of the synthetic amino acid analog PET radiotracer anti-3-18F-FACBC in breast lesions, with correlation to histologic and immunohistochemical characteristics. Page 1357

Coronary functional evaluation: Park and colleagues use a large national database to compare the clinical implications of coronary angiography and myocardial perfusion imaging in an initial evaluation for stable coronary artery disease. Page 1364

CZT vs. cardiofocal camera in LVF: Bailliez and colleagues compare 2 cadmium-zinc-telluride–detector SPECT cameras to a conventional Anger camera with cardiofocal collimators for assessment of left ventricular function in a phantom and patients. Page 1370

Noninvasive quantification of 11C-HED kinetics: Harms and colleagues investigate the feasibility of replacing arterial sampling of 11C-hydroxyephedrine kinetics in the myocardium with imaging-derived input function and venous blood samples. Page 1376

Myocardial dimensions from dynamic PET: Harms and colleagues explore the feasibility of measuring left ventricular geometry using dynamic 11C-acetate PET without electrocardiogram gating. Page 1382

First-in-human studies of brain PDE2A: Naganawa and colleagues report on a study of the novel phosphodiesterase-2A PET ligand 18F-PF-05270430 to determine the appropriate tracer kinetic model for brain uptake quantification and to examine within-subject test–retest variability. Page 1388

PET/MR imaging in spondylodiskitis: Fahnert and colleagues assess the diagnostic value of 18F-FDG PET combined with MR imaging in patients with suspected spondylodiskitis and inconclusive clinical or MR presentations. Page 1396

Comprehensive 68Ga generator QC: Amor-Coarasa and colleagues characterize the 1-y performance of a 68Ge/68Ga generator system in conjunction with production of 68Ga-labeled DOTATOC and 68Ga-PSMA-HBED-CC for clinical studies and establish protocols for batch release. Page 1402

Musculoskeletal infection: Palestro provides an educational overview of musculoskeletal infection imaging and the ways in which PET/CT and SPECT/CT are improving diagnostic accuracy and influencing management in patients with suspected or known infection and inflammation. Page 1406

RTK PET imaging for therapeutic guidance: Wehrenberg-Klee and colleagues describe development of PET probes that provide an in vivo method of imaging changes in receptor tyrosine kinase expression to identify tumors that use this “escape” pathway. Page 1413

Elucidating coronary plaque ruptures: Hermann and colleagues assess whether diet-induced coronary plaque ruptures trigger atherothrombotic occlusions, resulting in myocardial infarctions in a high-fat, high-cholesterol–fed hyperlipidemic mouse model. Page 1420

GM-CSF in glycolysis and inflammation: Singh and colleagues test the hypothesis that human granulocyte-macrophage colony-stimulating factor, a clinically used cytokine, increases macrophage glycolysis and deoxyglucose uptake in vitro and enhances 18F-FDG uptake in inflamed tissues in vivo. Page 1428

Preclinical evaluation P2X7R PET tracer: Ory and colleagues describe in rats and nonhuman primates the preclinical evaluation of 11C-JNJ-54173717, a PET tracer for the P2X7 receptor, which is associated with neuroinflammation. Page 1436

GABA and NMDA autoradiography of TBI: López-Picón and colleagues monitor changes in these key receptors in a clinically relevant rat model of induced traumatic brain injury using 2 new and specifically targeted PET ligands. Page 1442

Preclinical assessment of PDE2A tracer: Chen and colleagues image and quantify the activity of a novel enzyme phosphodiesterase 2A ligand in rats and nonhuman primates. Page 1448

Improved 18F-TFB synthesis: Jiang and colleagues detail the synthesis of 18F-tetrafluoroborate, a potential sodium/iodide symporter PET imaging probe, via direct radiofluorination on boron trifluoride and evaluate the influence of specific activity on tumor uptake. Page 1454

Microfluidic blood-counting system: Convert and colleagues propose a microfluidic counting system to monitor rodent blood radioactivity in real time, with high efficiency and small detection volume. Page 1460

Engineered human muscle precursor cells: Haralampieva and colleagues report on the design of an adenoviral delivery system to genetically modify human muscle precursor cells to express a signaling-deficient form of human dopamine D2 receptor for PET tracking of transplanted cells. Page 1467

PET mapping of PTSD: Zhu and colleagues use 18F-FDG PET to investigate neurobiologic changes before and after exposure-based therapy in a rat model of posttraumatic stress disorder. Page 1474

Administered activities in children: Fahey and colleagues report on results of a survey describing pediatric nuclear medicine practice at general hospitals in the United States and assessing the impact of dose awareness campaigns. Page 1478